What Is Normal Hair Growth and Common Hair Loss 2019

Normal hair growth and general hair loss

Normal hair growth and general hair loss

The normal hair growth cycle

Common Hair Loss: Undisturbed, each end scalp hair usually grows continuously for about 3-5 years. The hair then moves to a resting state where the visible part of the skin falls off. Hair does not grow for 90 days from hair follicles. After this time, new hair begins to grow through the skin and lasts an additional 3-5 years at a rate of about 1/2 inch a month.

As many as 100 genes are thought to be involved in the regulation of scalp generation, construction, and cycling. To date, very few of these genes have been identified.

Common pattern hair removal

Hamilton-Norwood Hair Removal Scale

People who are concerned about hair loss have a lot of myths and semi-truths, but getting useful information can be difficult. Thus, an objective overview of pattern hair removal is presented herein.

In healthy and nutritious individuals of both genders, the most common form of hair loss is androgenic alopecia (AGA), also known as pattern hair loss. The disease affects approximately 40 million American men. Perhaps surprisingly, the same disability affects about 20 million American women. The difference between men and women is that women who suffer from hair loss usually hold the hairline of her woman and experience thinning behind this cutting edge. In men, the loss of a clear "pattern" manifests itself as the leading edge recedes as the thinning area extends from the posterior crown. In more prominent cases, it is said that these zones meet and that the person is clinically bald.

Three triggers

Importantly, there are three things that need to be influenced by AGA. First, genetic predisposition must be inherited. This means that the problem arises from one or both sides of the family. Second, one needs to reach a certain age. Nine-year-old children do not experience pattern hair loss. And third, we need circulating hormones to accelerate the onset and progression of the disease.

Typically, the earliest onset of AGA occurs in late adolescence or early '20s. As a general rule, the earlier the hair removal, the more noticeable it will be.

Hormones, enzymes and other factors

Crystallography of DHT molecules
In terms of sensitivity, the main hormonal trigger associated with pattern hair loss is 5-alpha-dihydrotestosterone, commonly called DHT. Interestingly, it has been shown that hair loss does not occur in people who are genetically insensitive to DHT. DHT is synthesized from the androgen hormone testosterone and helps early in life and adolescence.

In adults, DHT is believed to cause serious harm, but it is not as good. Both totally different disorders, like benign prostatic hyperplasia and pattern alopecia, are caused by DHT. The synthesis of DHT occurs in two closely related forms of the enzyme 5-alpha reductase. Hair loss treatment options that effectively block the interaction between 5-alpha-reductase such as testosterone and the androgen hormone have been shown to provide clinical benefit in the treatment of pattern hair loss.

Because hair growth is controlled by multiple genes and their associated biochemical pathways, the underlying factors are quite complex. Another challenge to understanding hair loss was the fact that humans alone suffer from androgenic alopecia in mammals. Thus, there is no efficient animal model that would otherwise tend to shed light on key elements in the work.

Variations of hair loss other than AGA

In either gender, differential diagnosis is usually made based on the patient's medical history and clinical symptoms. Common differences in AGA include alopecia areata (AA), trichotillomania, and telogen hair loss. Less frequently, the cause of hair loss may be related to disorders such as lupus erythematosus, lichens or other disease processes that present with skin symptoms. Scalp biopsies and laboratory tests may be useful to confirm a definitive diagnosis, but in such cases, in general, should only follow the initial clinical evaluation by a qualified treating physician.

Pattern hair loss treatment options

The option to deal with hair loss is barely observed to be “rags, plugs, or drugs”. It clearly shows three treatment options called non-surgical hair system, surgical hair repair, and drug therapy. The fourth option has evolved recently. This is also mentioned here. This is a non-drug treatment.

Non-surgical repair

Typical hairpiece
Hair replacement systems have been used regularly, at least since ancient Egypt. These products are also called Hair Integration Systems, Wigs, Weaves, Hairpieces, Topics, etc. All have one thing in common. It does not grow from the scalp. Therefore, they must somehow be applied with either bald skin or hair fringes that are left over the ears and behind the scalp.
Such adherence to a living scalp is almost permanent and justified. Aside from the fact that the unit itself wears away, basic hygiene requires the wearer to remove the unit regularly to clean the underlying hair and scalp. There are almost three basic elements in the hair replacement system. The first is hair itself, which may be synthetic, natural, or a combination thereof. The second element is the bottom of the unit. Typically, the hair is woven into a cloth-like base, which is then attached to the scalp in some way. This will display the third element. This is a means of attachment. The method includes sewing the base to the fringe hair, adhering the base to fringe hair, or adhering the base to the scalp.
Potential benefits to the hair system include the immediacy of achieving a full hair "appearance" that may appear to a regular observer to approach full hair.
The potential disadvantages of hair systems square measure several and varied.

The hair system itself may rapidly accelerate the hair removal process, not the people who are actively removing hair, but the people who are essentially removing hair. Another disadvantage is the hard leading edge which can give up the fact that a person is wearing a hair system. To date, this problem has been addressed by using delicate lace-front artificial hair that looks very natural but is very fragile.
Because they are not alive, the hair system must provide service and eventually replace itself. The cost of maintaining and maintaining the hair replacement system is not important. Such costs can be much higher than the original purchase price.

Surgical hair repair
Surgical hair repair, commonly known as hair transplantation, utilizes the phenomenon first described in the 1950s. This phenomenon, donor dependence, creates a lively, vibrant hair that lasts in its new location when moved to a previously bald area of the same person's scalp, as it was otherwise. To do. Refers to the observation of continuation. "Replaced" # :. In properly selected patients, surgical hair repair to pattern hair loss is an effective solution
There are important points to note about hair transplantation. The first is demand and supply. At present, it is impossible to transplant hair from one person to another without causing a colorful and destructive foreign body response to the recipient. Thus, both the operator and the patient are forced to have permanent hair that holds the tissue in place. Therefore, it is very important to properly store and strategically place this valuable resource.
The second important point about hair transplantation is to achieve clinically useful endpoint results. Uneven or sudden hairlines may appear worse than before being restored. Similarly, hair behind the leading edge that is not repaired in such a way as to provide a meaningful density (e.g. 1 hair per mm2) often can not approach the entire hair's head. Thus, artistic excellence is at least as important as the basic surgical techniques in selecting a transplant surgeon.
The third precaution for hair transplantation is a problem known as chasing the receding hair. Because hair loss is progressive and unrelenting, recovered donor hair is integrated into the area of intact scalp hair and may become islands of hair as the back hair continues to erode. In this situation, the patient is forced to strengthen the hair behind the repair area to maintain a perfect appearance. This works pretty well until the hair stops thinning or the donor's hair disappears.
Ideally, it is useful for people undergoing transplant surgery to safely and effectively block the progress of hair loss and to incorporate treatment options that fill narrow areas, without having to worry about chasing the will of the receding hair It is.

Drug-based hair loss treatment options
From a therapeutic point of view, the two most widely used therapeutic interventions for pattern hair loss are topical minoxidil and oral finasteride.


Minoxidil, first marketed under the trade name Logain®, was first developed as the oral antihypertensive drug Roniten®. In some patients treated with blood pressure problems using Minoxidil, it was observed that abnormal hair growth occurred on the face and scalp. This was spoken colloquially as the influence of acupuncture. > From this observation, topical compositions containing Minoxidil have been successfully tested on the bald scalp. Rogaine® (2% minoxidil) was the first hair loss treatment approved by the FDA for use in men. Finally, RogaineTM (2% minoxidil) was approved for use in women. Extra Strength Rogen (TM) (5% Minoxidil) was approved by the FDA for use in men only.

The benefits of Rogaine (TM) include the ability to arrest and possibly reverse pattern hair loss. Based on Pfizer's proprietary marketing materials, Rogaine (TM) has been shown to be effective in treating hair loss in the parietal and posterior scalp but not in front hair growth. Minoxidil is a potent drug with potential side effects such as hypotension and skin inflammation.


Finasteride, a selective type II 5-alpha-reductase inhibitor, was originally developed under the tradename ProscarTM at an oral dose of 5 mg to treat benign prostatic hyperplasia (BPH). Since BPH is biochemically related to the same metabolic pathway that causes pattern alopecia, it was hypothesized that finasteride could be clinically useful in both pathologies. From this study, PropeciaTM (1 mg finasteride) was developed. In a placebo-controlled study of men with mild to moderate hair loss, Propecia (TM) may have clinically relevant benefits in blocking the progression of the disease and in some cases reversing the progression Indicated. Propecia (TM) is not adapted for use in women. Notable side effects include decreased libido and decreased ejaculation volume. Gynecomastia (male breast hypertrophy) is another potential side effect. Finasteride can also artificially reduce the levels of key proteins (PSA) used to screen for prostate cancer. Finasteride is considered a teratogen (possibly causing feminizing congenital defects) and should not be treated by a pregnant woman or anyone who may be in contact with a pregnant woman.


Like finasteride, dutasteride was originally developed to treat BPH. However, unlike finasteride, dutasteride inhibits both isoforms of 5-alpha-reductase, while finasteride inhibits only type II 5-alpha-reductase. Interestingly, in the clinical trials conducted by the EPICS study GlaxoSmithKline, dutasteride was not found to be more effective than finasteride in treating BPH.

Currently, dutasteride is approved for the treatment of BPH. A clinical trial of dutasteride as a depilatory was done but was discontinued in late 2002. Potential side effects associated with the use of dutasteride include gynecomastia, changes in PSA levels, and teratogenic effects. Manufacturer of finasteride.

In December 2006, GlaxoSmithKline will study 6 months in Korea to test the safety, tolerability, and efficacy of a once-daily dose of dutasteride (0.5 mg) for AGA treatment in the apical area of ​​the scalp. Hamilton-Norwood scale types IIIv, IV and V) embarked on a new phase III trial. The future impact of this study on FDA approval or non-approval of the FDA abodert for the treatment of male baldness in the United States has not yet been determined.

Other medicine

Occasionally, but particularly in female patients, drugs containing spironolactone and flutamide have sometimes been used out of the box to treat various forms of hair loss. Each drug has many potential side effects and none has been approved by the FDA for treatment of pattern hair loss.

Non-drug based hair loss treatment options

Recently, plant-derived materials are being seriously studied as potentially useful tools for AGA. This effort has been largely pioneered by the manufacturers of HairGenesisTM. After the creation of HairGenesis (TM), many other products came to market. Some incorporate drugs such as minoxidil. Others used non-drug based formulation themed variations. However, there is no third party IRB monitoring, placebo-controlled, double-blinded trial support except HairGenesisTM-published in the peer-reviewed medical literature. This makes HairGenesis (TM) unique in its category. For those who want to know how HairGenesisTM is considered to be compared with other hair loss treatment options, we recommend a review of the HairGenesisTM comparison page.

As the majority of this website focuses on the benefits associated with HairGenesisTM, many points supporting HairGenesisTM treatment will not be repeated here. However, two points are relevant to this discussion and will be briefly described.

First, the complexes of naturally occurring active substances used in HairGenesis (TM) act independently of one another through pathways and mechanisms unique to each other and apart from those on which drug-based therapies work Was shown to work. This observation should be enough to say that it provided a unique opportunity to develop HairGenesis into a "cocktail" treatment, where the synergy of the formulation is most likely to occur.

In plain English, this means that HairGenesisTM is designed to be larger than the sum of its parts.

The second point is that the manufacturers of HairGenesisTM are actively researching, and new, more advanced and more powerful versions are being developed. Such improvements will be reported accordingly.

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